RapamycinFungusV1, Main, Exploration, bibRecord, 000642

CLIP and cohibin separate rDNA from nucleolar proteins destined for degradation by nucleophagy.

Identifieur interne : 000642 ( Main/Exploration ); précédent : 000641; suivant : 000643

CLIP and cohibin separate rDNA from nucleolar proteins destined for degradation by nucleophagy.

Auteurs : Md Golam Mostofa [Japon] ; Muhammad Arifur Rahman [Japon] ; Naoki Koike [Japon] ; Akter Mst Yeasmin [Japon] ; Nafisa Islam [Japon] ; Talukdar Muhammad Waliullah [Japon] ; Shun Hosoyamada [Japon] ; Mitsugu Shimobayashi [Suisse] ; Takehiko Kobayashi [Japon] ; Michael N. Hall [Suisse] ; Takashi Ushimaru [Oman, Japon]

Source :

The Journal of cell biology [ 1540-8140 ] ; 2018.

RBID : pubmed:29959231

Descripteurs français

English descriptors

KwdEn :
- Autophagy (physiology), Cell Survival (MeSH), Chromatin Immunoprecipitation (MeSH), DNA, Ribosomal (metabolism), Nuclear Proteins (genetics), Nuclear Proteins (metabolism), Nuclear Proteins (physiology), Proteolysis (MeSH), Saccharomyces cerevisiae (genetics), Saccharomyces cerevisiae (metabolism), Saccharomyces cerevisiae Proteins (genetics), Saccharomyces cerevisiae Proteins (metabolism), Saccharomyces cerevisiae Proteins (physiology), Transcription Factors (genetics), Transcription Factors (metabolism), Transcription Factors (physiology).
MESH :
- chemical , genetics : Nuclear Proteins, Saccharomyces cerevisiae Proteins, Transcription Factors.
- chemical , metabolism : DNA, Ribosomal, Nuclear Proteins, Saccharomyces cerevisiae Proteins, Transcription Factors.
- genetics : Saccharomyces cerevisiae.
- metabolism : Saccharomyces cerevisiae.
- physiology : Autophagy, Nuclear Proteins, Saccharomyces cerevisiae Proteins, Transcription Factors.
- Cell Survival, Chromatin Immunoprecipitation, Proteolysis.

Abstract

Nutrient starvation or inactivation of target of rapamycin complex 1 (TORC1) in budding yeast induces nucleophagy, a selective autophagy process that preferentially degrades nucleolar components. DNA, including ribosomal DNA (rDNA), is not degraded by nucleophagy, even though rDNA is embedded in the nucleolus. Here, we show that TORC1 inactivation promotes relocalization of nucleolar proteins and rDNA to different sites. Nucleolar proteins move to sites proximal to the nuclear-vacuolar junction (NVJ), where micronucleophagy (or piecemeal microautophagy of the nucleus) occurs, whereas rDNA dissociates from nucleolar proteins and moves to sites distal to NVJs. CLIP and cohibin, which tether rDNA to the inner nuclear membrane, were required for repositioning of nucleolar proteins and rDNA, as well as effective nucleophagic degradation of the nucleolar proteins. Furthermore, micronucleophagy itself was necessary for the repositioning of rDNA and nucleolar proteins. However, rDNA escaped from nucleophagic degradation in CLIP- or cohibin-deficient cells. This study reveals that rDNA-nucleolar protein separation is important for the nucleophagic degradation of nucleolar proteins.

DOI: 10.1083/jcb.201706164
PubMed: 29959231
PubMed Central: PMC6080932

Affiliations:

Links toward previous steps (curation, corpus...)

to stream Main, to step Corpus: 000516
to stream Main, to step Curation: 000516

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">CLIP and cohibin separate rDNA from nucleolar proteins destined for degradation by nucleophagy.</title>
<author><name sortKey="Mostofa, Md Golam" sort="Mostofa, Md Golam" uniqKey="Mostofa M" first="Md Golam" last="Mostofa">Md Golam Mostofa</name>
<affiliation wicri:level="1"><nlm:affiliation>Graduate School of Science and Technology, Shizuoka University, Shizuoka, Japan.</nlm:affiliation>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Graduate School of Science and Technology, Shizuoka University, Shizuoka</wicri:regionArea>
<wicri:noRegion>Shizuoka</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Rahman, Muhammad Arifur" sort="Rahman, Muhammad Arifur" uniqKey="Rahman M" first="Muhammad Arifur" last="Rahman">Muhammad Arifur Rahman</name>
<affiliation wicri:level="1"><nlm:affiliation>Graduate School of Science and Technology, Shizuoka University, Shizuoka, Japan.</nlm:affiliation>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Graduate School of Science and Technology, Shizuoka University, Shizuoka</wicri:regionArea>
<wicri:noRegion>Shizuoka</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Koike, Naoki" sort="Koike, Naoki" uniqKey="Koike N" first="Naoki" last="Koike">Naoki Koike</name>
<affiliation wicri:level="1"><nlm:affiliation>Graduate School of Science and Technology, Shizuoka University, Shizuoka, Japan.</nlm:affiliation>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Graduate School of Science and Technology, Shizuoka University, Shizuoka</wicri:regionArea>
<wicri:noRegion>Shizuoka</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Yeasmin, Akter Mst" sort="Yeasmin, Akter Mst" uniqKey="Yeasmin A" first="Akter Mst" last="Yeasmin">Akter Mst Yeasmin</name>
<affiliation wicri:level="1"><nlm:affiliation>Graduate School of Science and Technology, Shizuoka University, Shizuoka, Japan.</nlm:affiliation>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Graduate School of Science and Technology, Shizuoka University, Shizuoka</wicri:regionArea>
<wicri:noRegion>Shizuoka</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Islam, Nafisa" sort="Islam, Nafisa" uniqKey="Islam N" first="Nafisa" last="Islam">Nafisa Islam</name>
<affiliation wicri:level="1"><nlm:affiliation>Course of Biological Science, Department of Science, Graduate School of Integrated Science and Technology, Shizuoka University, Shizuoka, Japan.</nlm:affiliation>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Course of Biological Science, Department of Science, Graduate School of Integrated Science and Technology, Shizuoka University, Shizuoka</wicri:regionArea>
<wicri:noRegion>Shizuoka</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Waliullah, Talukdar Muhammad" sort="Waliullah, Talukdar Muhammad" uniqKey="Waliullah T" first="Talukdar Muhammad" last="Waliullah">Talukdar Muhammad Waliullah</name>
<affiliation wicri:level="1"><nlm:affiliation>Graduate School of Science and Technology, Shizuoka University, Shizuoka, Japan.</nlm:affiliation>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Graduate School of Science and Technology, Shizuoka University, Shizuoka</wicri:regionArea>
<wicri:noRegion>Shizuoka</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hosoyamada, Shun" sort="Hosoyamada, Shun" uniqKey="Hosoyamada S" first="Shun" last="Hosoyamada">Shun Hosoyamada</name>
<affiliation wicri:level="4"><nlm:affiliation>Laboratory of Genome Regeneration, Institute of Molecular and Cellular Biosciences, University of Tokyo, Tokyo, Japan.</nlm:affiliation>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Laboratory of Genome Regeneration, Institute of Molecular and Cellular Biosciences, University of Tokyo, Tokyo</wicri:regionArea>
<placeName><settlement type="city">Tokyo</settlement>
<region type="région">Région de Kantō</region>
</placeName>
<orgName type="university">Université de Tokyo</orgName>
</affiliation>
</author>
<author><name sortKey="Shimobayashi, Mitsugu" sort="Shimobayashi, Mitsugu" uniqKey="Shimobayashi M" first="Mitsugu" last="Shimobayashi">Mitsugu Shimobayashi</name>
<affiliation wicri:level="1"><nlm:affiliation>Biozentrum, University of Basel, Basel, Switzerland.</nlm:affiliation>
<country xml:lang="fr">Suisse</country>
<wicri:regionArea>Biozentrum, University of Basel, Basel</wicri:regionArea>
<wicri:noRegion>Basel</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kobayashi, Takehiko" sort="Kobayashi, Takehiko" uniqKey="Kobayashi T" first="Takehiko" last="Kobayashi">Takehiko Kobayashi</name>
<affiliation wicri:level="4"><nlm:affiliation>Laboratory of Genome Regeneration, Institute of Molecular and Cellular Biosciences, University of Tokyo, Tokyo, Japan.</nlm:affiliation>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Laboratory of Genome Regeneration, Institute of Molecular and Cellular Biosciences, University of Tokyo, Tokyo</wicri:regionArea>
<placeName><settlement type="city">Tokyo</settlement>
<region type="région">Région de Kantō</region>
</placeName>
<orgName type="university">Université de Tokyo</orgName>
</affiliation>
</author>
<author><name sortKey="Hall, Michael N" sort="Hall, Michael N" uniqKey="Hall M" first="Michael N" last="Hall">Michael N. Hall</name>
<affiliation wicri:level="1"><nlm:affiliation>Biozentrum, University of Basel, Basel, Switzerland.</nlm:affiliation>
<country xml:lang="fr">Suisse</country>
<wicri:regionArea>Biozentrum, University of Basel, Basel</wicri:regionArea>
<wicri:noRegion>Basel</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ushimaru, Takashi" sort="Ushimaru, Takashi" uniqKey="Ushimaru T" first="Takashi" last="Ushimaru">Takashi Ushimaru</name>
<affiliation wicri:level="1"><nlm:affiliation>Graduate School of Science and Technology, Shizuoka University, Shizuoka, Japan takashi.ushimaru@gmail.com.</nlm:affiliation>
<country wicri:rule="url">Oman</country>
<wicri:regionArea>Graduate School of Science and Technology, Shizuoka University, Shizuoka</wicri:regionArea>
<wicri:noRegion>Shizuoka</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:affiliation>Course of Biological Science, Department of Science, Graduate School of Integrated Science and Technology, Shizuoka University, Shizuoka, Japan.</nlm:affiliation>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Course of Biological Science, Department of Science, Graduate School of Integrated Science and Technology, Shizuoka University, Shizuoka</wicri:regionArea>
<wicri:noRegion>Shizuoka</wicri:noRegion>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2018">2018</date>
<idno type="RBID">pubmed:29959231</idno>
<idno type="pmid">29959231</idno>
<idno type="doi">10.1083/jcb.201706164</idno>
<idno type="pmc">PMC6080932</idno>
<idno type="wicri:Area/Main/Corpus">000516</idno>
<idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000516</idno>
<idno type="wicri:Area/Main/Curation">000516</idno>
<idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000516</idno>
<idno type="wicri:Area/Main/Exploration">000516</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">CLIP and cohibin separate rDNA from nucleolar proteins destined for degradation by nucleophagy.</title>
<author><name sortKey="Mostofa, Md Golam" sort="Mostofa, Md Golam" uniqKey="Mostofa M" first="Md Golam" last="Mostofa">Md Golam Mostofa</name>
<affiliation wicri:level="1"><nlm:affiliation>Graduate School of Science and Technology, Shizuoka University, Shizuoka, Japan.</nlm:affiliation>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Graduate School of Science and Technology, Shizuoka University, Shizuoka</wicri:regionArea>
<wicri:noRegion>Shizuoka</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Rahman, Muhammad Arifur" sort="Rahman, Muhammad Arifur" uniqKey="Rahman M" first="Muhammad Arifur" last="Rahman">Muhammad Arifur Rahman</name>
<affiliation wicri:level="1"><nlm:affiliation>Graduate School of Science and Technology, Shizuoka University, Shizuoka, Japan.</nlm:affiliation>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Graduate School of Science and Technology, Shizuoka University, Shizuoka</wicri:regionArea>
<wicri:noRegion>Shizuoka</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Koike, Naoki" sort="Koike, Naoki" uniqKey="Koike N" first="Naoki" last="Koike">Naoki Koike</name>
<affiliation wicri:level="1"><nlm:affiliation>Graduate School of Science and Technology, Shizuoka University, Shizuoka, Japan.</nlm:affiliation>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Graduate School of Science and Technology, Shizuoka University, Shizuoka</wicri:regionArea>
<wicri:noRegion>Shizuoka</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Yeasmin, Akter Mst" sort="Yeasmin, Akter Mst" uniqKey="Yeasmin A" first="Akter Mst" last="Yeasmin">Akter Mst Yeasmin</name>
<affiliation wicri:level="1"><nlm:affiliation>Graduate School of Science and Technology, Shizuoka University, Shizuoka, Japan.</nlm:affiliation>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Graduate School of Science and Technology, Shizuoka University, Shizuoka</wicri:regionArea>
<wicri:noRegion>Shizuoka</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Islam, Nafisa" sort="Islam, Nafisa" uniqKey="Islam N" first="Nafisa" last="Islam">Nafisa Islam</name>
<affiliation wicri:level="1"><nlm:affiliation>Course of Biological Science, Department of Science, Graduate School of Integrated Science and Technology, Shizuoka University, Shizuoka, Japan.</nlm:affiliation>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Course of Biological Science, Department of Science, Graduate School of Integrated Science and Technology, Shizuoka University, Shizuoka</wicri:regionArea>
<wicri:noRegion>Shizuoka</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Waliullah, Talukdar Muhammad" sort="Waliullah, Talukdar Muhammad" uniqKey="Waliullah T" first="Talukdar Muhammad" last="Waliullah">Talukdar Muhammad Waliullah</name>
<affiliation wicri:level="1"><nlm:affiliation>Graduate School of Science and Technology, Shizuoka University, Shizuoka, Japan.</nlm:affiliation>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Graduate School of Science and Technology, Shizuoka University, Shizuoka</wicri:regionArea>
<wicri:noRegion>Shizuoka</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hosoyamada, Shun" sort="Hosoyamada, Shun" uniqKey="Hosoyamada S" first="Shun" last="Hosoyamada">Shun Hosoyamada</name>
<affiliation wicri:level="4"><nlm:affiliation>Laboratory of Genome Regeneration, Institute of Molecular and Cellular Biosciences, University of Tokyo, Tokyo, Japan.</nlm:affiliation>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Laboratory of Genome Regeneration, Institute of Molecular and Cellular Biosciences, University of Tokyo, Tokyo</wicri:regionArea>
<placeName><settlement type="city">Tokyo</settlement>
<region type="région">Région de Kantō</region>
</placeName>
<orgName type="university">Université de Tokyo</orgName>
</affiliation>
</author>
<author><name sortKey="Shimobayashi, Mitsugu" sort="Shimobayashi, Mitsugu" uniqKey="Shimobayashi M" first="Mitsugu" last="Shimobayashi">Mitsugu Shimobayashi</name>
<affiliation wicri:level="1"><nlm:affiliation>Biozentrum, University of Basel, Basel, Switzerland.</nlm:affiliation>
<country xml:lang="fr">Suisse</country>
<wicri:regionArea>Biozentrum, University of Basel, Basel</wicri:regionArea>
<wicri:noRegion>Basel</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kobayashi, Takehiko" sort="Kobayashi, Takehiko" uniqKey="Kobayashi T" first="Takehiko" last="Kobayashi">Takehiko Kobayashi</name>
<affiliation wicri:level="4"><nlm:affiliation>Laboratory of Genome Regeneration, Institute of Molecular and Cellular Biosciences, University of Tokyo, Tokyo, Japan.</nlm:affiliation>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Laboratory of Genome Regeneration, Institute of Molecular and Cellular Biosciences, University of Tokyo, Tokyo</wicri:regionArea>
<placeName><settlement type="city">Tokyo</settlement>
<region type="région">Région de Kantō</region>
</placeName>
<orgName type="university">Université de Tokyo</orgName>
</affiliation>
</author>
<author><name sortKey="Hall, Michael N" sort="Hall, Michael N" uniqKey="Hall M" first="Michael N" last="Hall">Michael N. Hall</name>
<affiliation wicri:level="1"><nlm:affiliation>Biozentrum, University of Basel, Basel, Switzerland.</nlm:affiliation>
<country xml:lang="fr">Suisse</country>
<wicri:regionArea>Biozentrum, University of Basel, Basel</wicri:regionArea>
<wicri:noRegion>Basel</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ushimaru, Takashi" sort="Ushimaru, Takashi" uniqKey="Ushimaru T" first="Takashi" last="Ushimaru">Takashi Ushimaru</name>
<affiliation wicri:level="1"><nlm:affiliation>Graduate School of Science and Technology, Shizuoka University, Shizuoka, Japan takashi.ushimaru@gmail.com.</nlm:affiliation>
<country wicri:rule="url">Oman</country>
<wicri:regionArea>Graduate School of Science and Technology, Shizuoka University, Shizuoka</wicri:regionArea>
<wicri:noRegion>Shizuoka</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:affiliation>Course of Biological Science, Department of Science, Graduate School of Integrated Science and Technology, Shizuoka University, Shizuoka, Japan.</nlm:affiliation>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Course of Biological Science, Department of Science, Graduate School of Integrated Science and Technology, Shizuoka University, Shizuoka</wicri:regionArea>
<wicri:noRegion>Shizuoka</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j">The Journal of cell biology</title>
<idno type="eISSN">1540-8140</idno>
<imprint><date when="2018" type="published">2018</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Autophagy (physiology)</term>
<term>Cell Survival (MeSH)</term>
<term>Chromatin Immunoprecipitation (MeSH)</term>
<term>DNA, Ribosomal (metabolism)</term>
<term>Nuclear Proteins (genetics)</term>
<term>Nuclear Proteins (metabolism)</term>
<term>Nuclear Proteins (physiology)</term>
<term>Proteolysis (MeSH)</term>
<term>Saccharomyces cerevisiae (genetics)</term>
<term>Saccharomyces cerevisiae (metabolism)</term>
<term>Saccharomyces cerevisiae Proteins (genetics)</term>
<term>Saccharomyces cerevisiae Proteins (metabolism)</term>
<term>Saccharomyces cerevisiae Proteins (physiology)</term>
<term>Transcription Factors (genetics)</term>
<term>Transcription Factors (metabolism)</term>
<term>Transcription Factors (physiology)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>ADN ribosomique (métabolisme)</term>
<term>Autophagie (physiologie)</term>
<term>Facteurs de transcription (génétique)</term>
<term>Facteurs de transcription (métabolisme)</term>
<term>Facteurs de transcription (physiologie)</term>
<term>Immunoprécipitation de la chromatine (MeSH)</term>
<term>Protéines de Saccharomyces cerevisiae (génétique)</term>
<term>Protéines de Saccharomyces cerevisiae (métabolisme)</term>
<term>Protéines de Saccharomyces cerevisiae (physiologie)</term>
<term>Protéines nucléaires (génétique)</term>
<term>Protéines nucléaires (métabolisme)</term>
<term>Protéines nucléaires (physiologie)</term>
<term>Protéolyse (MeSH)</term>
<term>Saccharomyces cerevisiae (génétique)</term>
<term>Saccharomyces cerevisiae (métabolisme)</term>
<term>Survie cellulaire (MeSH)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Nuclear Proteins</term>
<term>Saccharomyces cerevisiae Proteins</term>
<term>Transcription Factors</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>DNA, Ribosomal</term>
<term>Nuclear Proteins</term>
<term>Saccharomyces cerevisiae Proteins</term>
<term>Transcription Factors</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Saccharomyces cerevisiae</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Facteurs de transcription</term>
<term>Protéines de Saccharomyces cerevisiae</term>
<term>Protéines nucléaires</term>
<term>Saccharomyces cerevisiae</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Saccharomyces cerevisiae</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>ADN ribosomique</term>
<term>Facteurs de transcription</term>
<term>Protéines de Saccharomyces cerevisiae</term>
<term>Protéines nucléaires</term>
<term>Saccharomyces cerevisiae</term>
</keywords>
<keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Autophagie</term>
<term>Facteurs de transcription</term>
<term>Protéines de Saccharomyces cerevisiae</term>
<term>Protéines nucléaires</term>
</keywords>
<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Autophagy</term>
<term>Nuclear Proteins</term>
<term>Saccharomyces cerevisiae Proteins</term>
<term>Transcription Factors</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Cell Survival</term>
<term>Chromatin Immunoprecipitation</term>
<term>Proteolysis</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Immunoprécipitation de la chromatine</term>
<term>Protéolyse</term>
<term>Survie cellulaire</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Nutrient starvation or inactivation of target of rapamycin complex 1 (TORC1) in budding yeast induces nucleophagy, a selective autophagy process that preferentially degrades nucleolar components. DNA, including ribosomal DNA (rDNA), is not degraded by nucleophagy, even though rDNA is embedded in the nucleolus. Here, we show that TORC1 inactivation promotes relocalization of nucleolar proteins and rDNA to different sites. Nucleolar proteins move to sites proximal to the nuclear-vacuolar junction (NVJ), where micronucleophagy (or piecemeal microautophagy of the nucleus) occurs, whereas rDNA dissociates from nucleolar proteins and moves to sites distal to NVJs. CLIP and cohibin, which tether rDNA to the inner nuclear membrane, were required for repositioning of nucleolar proteins and rDNA, as well as effective nucleophagic degradation of the nucleolar proteins. Furthermore, micronucleophagy itself was necessary for the repositioning of rDNA and nucleolar proteins. However, rDNA escaped from nucleophagic degradation in CLIP- or cohibin-deficient cells. This study reveals that rDNA-nucleolar protein separation is important for the nucleophagic degradation of nucleolar proteins.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">29959231</PMID>
<DateCompleted><Year>2019</Year>
<Month>07</Month>
<Day>16</Day>
</DateCompleted>
<DateRevised><Year>2019</Year>
<Month>07</Month>
<Day>16</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1540-8140</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>217</Volume>
<Issue>8</Issue>
<PubDate><Year>2018</Year>
<Month>08</Month>
<Day>06</Day>
</PubDate>
</JournalIssue>
<Title>The Journal of cell biology</Title>
<ISOAbbreviation>J Cell Biol</ISOAbbreviation>
</Journal>
<ArticleTitle>CLIP and cohibin separate rDNA from nucleolar proteins destined for degradation by nucleophagy.</ArticleTitle>
<Pagination><MedlinePgn>2675-2690</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1083/jcb.201706164</ELocationID>
<Abstract><AbstractText>Nutrient starvation or inactivation of target of rapamycin complex 1 (TORC1) in budding yeast induces nucleophagy, a selective autophagy process that preferentially degrades nucleolar components. DNA, including ribosomal DNA (rDNA), is not degraded by nucleophagy, even though rDNA is embedded in the nucleolus. Here, we show that TORC1 inactivation promotes relocalization of nucleolar proteins and rDNA to different sites. Nucleolar proteins move to sites proximal to the nuclear-vacuolar junction (NVJ), where micronucleophagy (or piecemeal microautophagy of the nucleus) occurs, whereas rDNA dissociates from nucleolar proteins and moves to sites distal to NVJs. CLIP and cohibin, which tether rDNA to the inner nuclear membrane, were required for repositioning of nucleolar proteins and rDNA, as well as effective nucleophagic degradation of the nucleolar proteins. Furthermore, micronucleophagy itself was necessary for the repositioning of rDNA and nucleolar proteins. However, rDNA escaped from nucleophagic degradation in CLIP- or cohibin-deficient cells. This study reveals that rDNA-nucleolar protein separation is important for the nucleophagic degradation of nucleolar proteins.</AbstractText>
<CopyrightInformation>© 2018 Mostofa et al.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Mostofa</LastName>
<ForeName>Md Golam</ForeName>
<Initials>MG</Initials>
<Identifier Source="ORCID">0000-0002-0488-9121</Identifier>
<AffiliationInfo><Affiliation>Graduate School of Science and Technology, Shizuoka University, Shizuoka, Japan.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Rahman</LastName>
<ForeName>Muhammad Arifur</ForeName>
<Initials>MA</Initials>
<Identifier Source="ORCID">0000-0002-9908-1474</Identifier>
<AffiliationInfo><Affiliation>Graduate School of Science and Technology, Shizuoka University, Shizuoka, Japan.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Koike</LastName>
<ForeName>Naoki</ForeName>
<Initials>N</Initials>
<AffiliationInfo><Affiliation>Graduate School of Science and Technology, Shizuoka University, Shizuoka, Japan.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Yeasmin</LastName>
<ForeName>Akter Mst</ForeName>
<Initials>AM</Initials>
<AffiliationInfo><Affiliation>Graduate School of Science and Technology, Shizuoka University, Shizuoka, Japan.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Islam</LastName>
<ForeName>Nafisa</ForeName>
<Initials>N</Initials>
<AffiliationInfo><Affiliation>Course of Biological Science, Department of Science, Graduate School of Integrated Science and Technology, Shizuoka University, Shizuoka, Japan.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Waliullah</LastName>
<ForeName>Talukdar Muhammad</ForeName>
<Initials>TM</Initials>
<Identifier Source="ORCID">0000-0001-9951-2871</Identifier>
<AffiliationInfo><Affiliation>Graduate School of Science and Technology, Shizuoka University, Shizuoka, Japan.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Hosoyamada</LastName>
<ForeName>Shun</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>Laboratory of Genome Regeneration, Institute of Molecular and Cellular Biosciences, University of Tokyo, Tokyo, Japan.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Shimobayashi</LastName>
<ForeName>Mitsugu</ForeName>
<Initials>M</Initials>
<Identifier Source="ORCID">0000-0002-6936-0990</Identifier>
<AffiliationInfo><Affiliation>Biozentrum, University of Basel, Basel, Switzerland.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Kobayashi</LastName>
<ForeName>Takehiko</ForeName>
<Initials>T</Initials>
<Identifier Source="ORCID">0000-0002-7990-3741</Identifier>
<AffiliationInfo><Affiliation>Laboratory of Genome Regeneration, Institute of Molecular and Cellular Biosciences, University of Tokyo, Tokyo, Japan.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Hall</LastName>
<ForeName>Michael N</ForeName>
<Initials>MN</Initials>
<AffiliationInfo><Affiliation>Biozentrum, University of Basel, Basel, Switzerland.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Ushimaru</LastName>
<ForeName>Takashi</ForeName>
<Initials>T</Initials>
<Identifier Source="ORCID">0000-0003-4589-7408</Identifier>
<AffiliationInfo><Affiliation>Graduate School of Science and Technology, Shizuoka University, Shizuoka, Japan takashi.ushimaru@gmail.com.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Course of Biological Science, Department of Science, Graduate School of Integrated Science and Technology, Shizuoka University, Shizuoka, Japan.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2018</Year>
<Month>06</Month>
<Day>29</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>United States</Country>
<MedlineTA>J Cell Biol</MedlineTA>
<NlmUniqueID>0375356</NlmUniqueID>
<ISSNLinking>0021-9525</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D004275">DNA, Ribosomal</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D009687">Nuclear Proteins</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D029701">Saccharomyces cerevisiae Proteins</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="C561842">TORC1 protein complex, S cerevisiae</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D014157">Transcription Factors</NameOfSubstance>
</Chemical>
</ChemicalList>
<CitationSubset>IM</CitationSubset>
<CommentsCorrectionsList><CommentsCorrections RefType="CommentIn"><RefSource>J Cell Biol. 2018 Aug 6;217(8):2605-2607</RefSource>
<PMID Version="1">30006460</PMID>
</CommentsCorrections>
</CommentsCorrectionsList>
<MeshHeadingList><MeshHeading><DescriptorName UI="D001343" MajorTopicYN="N">Autophagy</DescriptorName>
<QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D002470" MajorTopicYN="N">Cell Survival</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D047369" MajorTopicYN="N">Chromatin Immunoprecipitation</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D004275" MajorTopicYN="N">DNA, Ribosomal</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D009687" MajorTopicYN="N">Nuclear Proteins</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
<QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D059748" MajorTopicYN="N">Proteolysis</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D012441" MajorTopicYN="N">Saccharomyces cerevisiae</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D029701" MajorTopicYN="N">Saccharomyces cerevisiae Proteins</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
<QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D014157" MajorTopicYN="N">Transcription Factors</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
<QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName>
</MeshHeading>
</MeshHeadingList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="received"><Year>2017</Year>
<Month>06</Month>
<Day>29</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="revised"><Year>2018</Year>
<Month>02</Month>
<Day>15</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="accepted"><Year>2018</Year>
<Month>05</Month>
<Day>02</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="pubmed"><Year>2018</Year>
<Month>7</Month>
<Day>1</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline"><Year>2019</Year>
<Month>7</Month>
<Day>17</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="entrez"><Year>2018</Year>
<Month>7</Month>
<Day>1</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
</History>
<PublicationStatus>ppublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="pubmed">29959231</ArticleId>
<ArticleId IdType="pii">jcb.201706164</ArticleId>
<ArticleId IdType="doi">10.1083/jcb.201706164</ArticleId>
<ArticleId IdType="pmc">PMC6080932</ArticleId>
</ArticleIdList>
<ReferenceList><Reference><Citation>Nature. 2015 Jun 18;522(7556):359-62</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26040717</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Autophagy. 2009 Jan;5(1):75-81</Citation>
<ArticleIdList><ArticleId IdType="pubmed">18989095</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Biol Chem. 2004 Jul 16;279(29):29889-94</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15138258</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Yeast. 2000 Jun 30;16(9):857-60</Citation>
<ArticleIdList><ArticleId IdType="pubmed">10861908</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>PLoS One. 2010 Mar 23;5(3):e9806</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20352102</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nature. 2008 Dec 4;456(7222):667-70</Citation>
<ArticleIdList><ArticleId IdType="pubmed">18997772</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cell Death Dis. 2014 Jul 17;5:e1339</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25032862</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nat Rev Mol Cell Biol. 2009 Jul;10(7):458-67</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19491929</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Genetics. 2011 Dec;189(4):1177-201</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22174183</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>FEBS Lett. 1993 Oct 25;333(1-2):169-74</Citation>
<ArticleIdList><ArticleId IdType="pubmed">8224160</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Cell Biol. 2000 Oct 30;151(3):519-28</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11062254</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Biol Chem. 2004 Mar 12;279(11):9987-96</Citation>
<ArticleIdList><ArticleId IdType="pubmed">14679207</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Genetics. 2013 Jun;194(2):341-61</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23733851</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Mol Cell. 2015 Feb 5;57(3):456-66</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25601754</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>EMBO J. 2016 Nov 15;35(22):2447-2467</Citation>
<ArticleIdList><ArticleId IdType="pubmed">27733427</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Autophagy. 2007 Mar-Apr;3(2):85-92</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17204844</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>PLoS One. 2011 Feb 25;6(2):e17412</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21364763</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Science. 2012 Apr 13;336(6078):225-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22499945</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cell. 2004 May 14;117(4):441-53</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15137938</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Mol Biol Cell. 2003 Jan;14(1):129-41</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12529432</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cell Cycle. 2012 Jan 1;11(1):170-6</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22185757</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Mol Biol Cell. 2010 Dec;21(23):4173-83</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20943953</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Genes Cells. 2007 Jun;12(6):759-71</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17573776</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nature. 2015 Nov 5;527(7576):105-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26524528</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Mol Biol Cell. 2000 Jul;11(7):2445-57</Citation>
<ArticleIdList><ArticleId IdType="pubmed">10888680</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>PLoS One. 2010 Dec 20;5(12):e15650</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21187926</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Cell Biol. 2000 Oct 30;151(3):529-38</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11062255</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Biotechniques. 2007 Feb;42(2):158, 160, 162</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17373478</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Cell Biol. 1992 Oct;119(2):301-11</Citation>
<ArticleIdList><ArticleId IdType="pubmed">1400575</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Genes Cells. 2011 May;16(5):491-502</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21518153</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Mol Biol Cell. 2008 Oct;19(10):4492-505</Citation>
<ArticleIdList><ArticleId IdType="pubmed">18701704</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Cell Sci. 2004 Oct 1;117(Pt 21):4959-68</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15367582</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
</PubmedData>
</pubmed>
<affiliations><list><country><li>Japon</li>
<li>Oman</li>
<li>Suisse</li>
</country>
<region><li>Région de Kantō</li>
</region>
<settlement><li>Tokyo</li>
</settlement>
<orgName><li>Université de Tokyo</li>
</orgName>
</list>
<tree><country name="Japon"><noRegion><name sortKey="Mostofa, Md Golam" sort="Mostofa, Md Golam" uniqKey="Mostofa M" first="Md Golam" last="Mostofa">Md Golam Mostofa</name>
</noRegion>
<name sortKey="Hosoyamada, Shun" sort="Hosoyamada, Shun" uniqKey="Hosoyamada S" first="Shun" last="Hosoyamada">Shun Hosoyamada</name>
<name sortKey="Islam, Nafisa" sort="Islam, Nafisa" uniqKey="Islam N" first="Nafisa" last="Islam">Nafisa Islam</name>
<name sortKey="Kobayashi, Takehiko" sort="Kobayashi, Takehiko" uniqKey="Kobayashi T" first="Takehiko" last="Kobayashi">Takehiko Kobayashi</name>
<name sortKey="Koike, Naoki" sort="Koike, Naoki" uniqKey="Koike N" first="Naoki" last="Koike">Naoki Koike</name>
<name sortKey="Rahman, Muhammad Arifur" sort="Rahman, Muhammad Arifur" uniqKey="Rahman M" first="Muhammad Arifur" last="Rahman">Muhammad Arifur Rahman</name>
<name sortKey="Ushimaru, Takashi" sort="Ushimaru, Takashi" uniqKey="Ushimaru T" first="Takashi" last="Ushimaru">Takashi Ushimaru</name>
<name sortKey="Waliullah, Talukdar Muhammad" sort="Waliullah, Talukdar Muhammad" uniqKey="Waliullah T" first="Talukdar Muhammad" last="Waliullah">Talukdar Muhammad Waliullah</name>
<name sortKey="Yeasmin, Akter Mst" sort="Yeasmin, Akter Mst" uniqKey="Yeasmin A" first="Akter Mst" last="Yeasmin">Akter Mst Yeasmin</name>
</country>
<country name="Suisse"><noRegion><name sortKey="Shimobayashi, Mitsugu" sort="Shimobayashi, Mitsugu" uniqKey="Shimobayashi M" first="Mitsugu" last="Shimobayashi">Mitsugu Shimobayashi</name>
</noRegion>
<name sortKey="Hall, Michael N" sort="Hall, Michael N" uniqKey="Hall M" first="Michael N" last="Hall">Michael N. Hall</name>
</country>
<country name="Oman"><noRegion><name sortKey="Ushimaru, Takashi" sort="Ushimaru, Takashi" uniqKey="Ushimaru T" first="Takashi" last="Ushimaru">Takashi Ushimaru</name>
</noRegion>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Bois/explor/RapamycinFungusV1/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000642 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000642 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Bois
   |area=    RapamycinFungusV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     pubmed:29959231
   |texte=   CLIP and cohibin separate rDNA from nucleolar proteins destined for degradation by nucleophagy.
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i   -Sk "pubmed:29959231" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd   \
       | NlmPubMed2Wicri -a RapamycinFungusV1

This area was generated with Dilib version V0.6.38.
Data generation: Thu Nov 19 21:55:41 2020. Site generation: Thu Nov 19 22:00:39 2020

	Serveur d'exploration sur la rapamycine et les champignons
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Serveur d'exploration sur la rapamycine et les champignons

CLIP and cohibin separate rDNA from nucleolar proteins destined for degradation by nucleophagy.

CLIP and cohibin separate rDNA from nucleolar proteins destined for degradation by nucleophagy.

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki